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When demand risesthrough inflammation, toxin exposure, or intense physiologic stresscells can burn through antioxidant capacity faster than it is restored

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53 It has previously been shown that sulfasalazine exhibits limited efficacy in CD44-negative non-CSCs

Similar content being viewed by others 1 Introduction ASCVD is a result of a synergy of multiple pathogenic processes in the body, such as alterations in lipid metabolism, oxidative stress, vascular endothelium disorder, mitochondrial disfunction, genetic abnormalities, and inflammation, which is a multiphasic cascade of immune-inflammatory reactions and pathways, involving a number of factors and cellular elements [1]