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However, studies on the characterization of the GSH antioxidant system in exosomes are lacking

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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

Additionally, mitochondrial DNA mutations and reduced mitophagy exacerbate mitochondrial dysfunction and contribute to the progression of AD [158]

Glutathione is present in every cell, therefore every bodily system is affected by the levels of glutathione

doi: 10.1038/nature14319 110 AlessioNRiccitielloFSquillaroTCapassoSDel GaudioSDi BernardoGet al