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Determinants of heterogeneity in ARs transcriptional output AR-binding DNA motifs Most of the reported heterogeneity has been linked to the spectrum of AREs to which AR binds and to the protein interactome that the ARE-bound AR engages, or the chromatome, to alter expression patterns of its target genes (Fig

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2,12 Ovulation Dysfunction Ovulation disorders are caused by hormonal imbalance and account for approximately 25% of infertility cases, 3 and may be caused by one or more of the following: Genetics

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Body cells and tissues are threatened continuously by damage caused by toxic free radicals and reactive oxygen species (e.g., peroxides), which are produced during normal oxygen metabolism, by other chemical reactions, and by toxic agents in the environment