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Improved ADC efficacy: by reducing systemic side effects and increasing effective drug concentration within target cells, therapeutic outcomes are enhanced

Elevated concentrations of cell-free (cf) self-DNA in blood or plasma of COVID-19 patients have been reported repeatedly and in most cases, cfDNA levels correlated with disease severity (57, However, DAMPs-mediated signalling can also generate detrimental effects, particularly when a massive release of pro-inflammatory DAMPs from dying cells causes more cells to die: a situation that strongly contributes to the CD4+ T cell depletion in patients infected with HIV-1 (6670), including sepsis-like systemic inflammation (71), sepsis (72), can lead to myocarditis (7376) or lung inflammation (77), facilitates the reactivation of latent virus infections, including Herpes Simplex Virus, Varicella Zoster Virus, or HIV-1, and favours the development of autoimmune diseases such as systemic lupus erythematosus (SLE) and psoriasis (67, 76, 7886)

The gating strategy is described in Supplemental Figure 1

ISSN 1195-6860

Although toxic build-up of amyloid- is considered the primary driver of Alzheimers pathology, clinical attempts to lower A levels have so far failed to slow disease progression