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This compromised barrier function facilitates bacterial translocation while recruiting and activating pro-inflammatory immune cells, such as neutrophils and Th17 cells, thereby intensifying the inflammatory process (180)

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The peptide targets angiogenesis and modulates nitric oxide levels, counteracting free radicals while maintaining protective functions in preclinical animal models

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CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver