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MTT assay and cell apoptosis studies revealed significantly greater anticancer efficacy with mPEG- b -PCPT@DOX compared to the combination of free drugs, displaying excellent synergistic effect

195,237 Concurrently, AMPK activation curbs the activity of mTORC1, thereby inhibiting energy-consuming processes like gluconeogenesis, lipid synthesis, and protein synthesis

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[PubMed: 15585568] 225

[DOI] [PubMed] [Google Scholar] 64.Wolfroum S., Grimm M., Heidberder M., Dendorfer A., Kauts H., Liao K.G.R