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The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes
1998;63:PL1259
Side effects by dose A meta-analysis of 10 trials (6,836 participants) found total GI event rates of 39% at 5 mg, 46% at 10 mg, and 49% at 15 mg
However, these studies cannot definitely establish the absence of any risk because of methodological limitations, including small sample size and inconsistent comparator groups
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