dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants
Description
Let's take BPC157 for the moment
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://ars.els-cdn.com/content/image/1-s2.0-S0045653516316320-gr4.jpg)
It is loose
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://pubs.acs.org/cms/10.1021/acsomega.2c01393/asset/images/medium/ao2c01393_0003.gif)
In our trial, vitamin B-12supplemented mothers had higher blood vitamin B-12 concentrations during pregnancy but not significantly lower MMA or tHcy blood concentrations
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://www.researchgate.net/publication/8918738/figure/tbl5/AS:11431281127926369@1679225521642/Phenol-Substituents-and-Their-Observed-and-Predicted-pKa-Values-Obtained-at-Level-E-Using.png)
This is the bedrock of reliable science
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://optibrium.com/wp-content/uploads/2024/06/pKa-prediction-using-quantum-mechanics-and-machine-learning-.png)
It means there is no established dosing standard, no agreed safety profile for reproductive use, and no clear proof it helps fertility outcomes
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://cdn.masterorganicchemistry.com/wp-content/uploads/quiz-images/2376-Front.gif)
Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight
![dihexa predicted pka of [ 18 F]AV1451 by property prediction and comparison of Determination of acid dissociation constants](https://www.chemicalbook.com/CAS/20200611/GIF/1401708-83-5.gif)