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Here, we investigated whether hypoxia-induced HIF-1 activation enriches miR-146b in Hypo-Exos, thereby modulating neuroinflammation via ubiquitination pathways in ICH

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An in vitro study using AD fibroblasts revealed a reduction of oxoglutarate dehydrogenase activity and it was further supported by an in vivo study with AD patients whereby the activity of oxoglutarate dehydrogenase complex was markedly reduced by 46 to 68% [201, 202]

doi: 10.1016/j.cytogfr.2004.11.001 259 RibattiDVaccaA

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