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For C677T, the enzyme activity of heterozygous and homozygous mutant individuals are respectively 67 and 25% of the wild-type ones

DHA is generated from MDHA

Since the synthesis and expression of GPx4 are regulated by various cellular processes, targeting GPx4 may constitute a promising strategy for the induction of ferroptosis and the promotion of cancer cell death in treatment-resistant cancers (Lee and Roh 2023)

Antioxid Redox Signaling (2014) 20(3):391402

Perform linear regression analysis to determine the slope and intercept of the curve

Huaier suppresses lung cancer by simultaneously and independently inhibiting the antioxidant pathway SLC7A11/GPX4 while enhancing ferritinophagy