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If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability

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Outcome findings from pairwise meta-analysis The pooled SMDs for overall pain assessment between treatments versus the control group was -0.33 (95% CI: -0.52, -0.14)

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(2014) Meta-analysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropathy