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To mitigate these concerns, we prioritized age-appropriate pediatric controls, used the adult dataset only for cell-type annotation, and performed sensitivity analyses using Asia-based external cohorts, which supported the directionality of key CD4 T cellrelated findings

Functional assays recapitulating the pro-tumour behaviour and progression, showed that ALCAR reduces cell growth and hinders PCa and BPH cell migration, and invasion, and limits MMP-9 production

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