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A second regulatory layer involves histone post-translational modifications, such as acetylation (for example H3K9ac) or methylation (for example H3K9me3 and H3K27me3), which remodel chromatin to activate or repress transcription

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Gain-of-function of LRRK2 mutations disturb mitochondrial bioenergetics and mitochondrial dynamics leading to increased ROS formation [246, 256]

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Chemotherapy drug Lobaplatin triggers pyroptosis in cervical cancer and colorectal cancer by activating GSDME (Chen et al., 2022)