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Eventually, a primary dysfunction of NMDARs, or neuroinflammation, or mitochondrial dysfunction, or impaired regulation of antioxidant systems could involve in turn the other vicious circles, all converging to common deleterious impacts on PV neurons and oligodendrocytes during neurodevelopment (Fig

Reported incidence rates vary widely depending on the study population [222,223,224]

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In the p16-CDK4-RB pathway, RB is activated through phosphorylation by the cyclin dependent kinase (CDK) 4/6-cyclin D1 complex

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