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However, while some studies noted increased vanin-1 activity in diabetic models, the absence of vanin-1 resulted in only mild improvements in glucose tolerance and insulin sensitivity 41
Among these, vitamin E can play a neuroprotective role in neurodegeneration with respect to PD

Due to differences in tissue culture and immunocytochemical techniques, there is still no clear conclusion on whether D-serine is distributed in astroglia or neurons, and Coyle et al

In addition, the concentration ranges used are much higher than the levels of circulating bioavailable metabolites

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