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In the cytosol, several metabolic pathways lead to its formation, namely, glycolysis, the oxidation of lactate, the reaction catalyzed by the cytosolic malic enzyme, and the catabolism of at least six amino acids, the most important of which is alanine

Michniewicz F, Saletta F, Rouaen JRC, Hewavisenti RV, Mercatelli D, Cirillo G, et al

The studies highlight its effects in the regulation of Th17/Treg populations [79], promoting the proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways [80], enhancing the polarization of the anti-inflammatory phenotype in macrophages (M2) [81]

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