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In the NAFLD model of zebrafish, we observed that swimming exercise can inhibit excessive ROS production, reduce caspase-3 and Bax expression, and increase Bcl-2 levels by activating recombinant Sirtuin 1 (SIRT1)/AMP-activated protein kinase (AMPK) signaling-mediated NRF2, which in turn reduces oxidative stress and ROS-induced apoptosis in zebrafish liver, decreases lipid accumulation in zebrafish NAFLD model liver, and attenuates liver injury [31]

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Notably, DCVC-induced changes in cellular function and toxicity were more severe when BeWo cells either were undergoing or had completed syncytialization (111, 112)

Chemokines binding to specific receptors on the target cell membrane help to recruit immune cells into the tumor microenvironment, thereby managing immune surveillance, angiogenesis, invasion and metastasis (96)

Finally, the treatment duration we chose in our study is similar to that of previous studies [10] in which effects were found in the follow-up period but not at the end of treatment

doi: 10.1016/j.biopha.2023.116042 104 LiuZKangRYangNPanXYangJYuHet al