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doi:10.1016/S0736-0266(03)00110-4

The study found that up to around half of all autoimmune thyroid patients had a vitamin B-12 deficiency
Lastly, the partly indirect system is a hybrid of the two

They go directly into the bloodstream and begin working almost immediately

While definitive conclusions are premature, the assumption that unlimited B12 is harmless deserves ongoing scrutiny

Higher NNMT activity means more nicotinamide gets shunted away from NAD+ production