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Statements Author contributions SK organized the general content of the manuscript

In conditions like Long COVID, researchers have identified widespread endothelial dysfunctiondamage to the inner lining of the blood vesselsand the presence of persistent micro-clots

4 The combination of unresolved biomechanical and biochemical stress promotes secondary alterations which lead to a predominant catabolic microenvironment

70,71 Moreover, for invertebrates that lack a vascularized circulatory system, astrocytes are the main components of the barrier separating humoral fluids from the CNS

Protease-antiprotease balance is extremely disrupted in severe bronchiectasis, as shown in proteomic studies of sputum from patients with bronchiectasis that demonstrated that both elevated NSPs and reduced secretory leukocyte protease inhibitor levels were associated with disease severity (117, 118)

The primary outcome would be change in depressive symptom severity over 812 weeks using validated clinician-rated scales, with secondary outcomes including response and remission rates, anxiety, fatigue, cognitive function, sleep quality, and quality of life