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DHFR has been previously reported to be related to the thymidylate cycle [12] and is the target enzyme of pemetrexed [13]
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4.1 Loss of gray matter, white matter, and hippocampal volume The loss of GM, WM, and hippocampal volume, as well as WMLs, is believed to underlie DM-associated cognitive dysfunction (100)
doi: 10.1056/NEJMoa012561 206 SethiS.MurphyT
