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Description
Chemical Name: 5-Amino-1MQ
Common: Local injection site pain, mild allergic reactions
It enhances biochemical signaling for collagen and glycosaminoglycan production, recruits immune and endothelial cells to injury sites, and promotes remodeling of connective tissue
Mechanistically, overexpression of CD36 increases lipid peroxidation, mitochondrial ROS production, the labile iron pool, and especially Fe2+ content
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However, resistance to these therapies occurs in about half of patients, leading to decreased survival rates
