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Growing evidence from independent groups highlights that autophagy promotes iron accumulation and lipid peroxidation, key metabolic hallmarks of ferroptosis (14, 15)
Further, alteration in its DNA methylation levels, assessed by measuring the CpG islands from the Exon IV of the BDNF gene, was shown to be associated with bipolar disorder and major depression (Kundakovic et al., 2015)
Biomark Med 8:321330 Tschinkel PFS, Bjrklund G, Conn LZZ, Chirumbolo S, Nascimento VA (2018) Plasma concentrations of the trace elements copper, zinc and selenium in Brazilian children with autism spectrum disorder
(607) Besedovsky, H
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It is also important to note that no safety issues can be detected when consuming creatine long-term [62,63]
