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Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19

Antioxid Redox Signal 15:19571997
Because it can form adducts with DNA, proteins, and lipids, 4-HNE is both genotoxic and cytotoxic, and is causally involved in several human pathologies including cardiac and neurodegenerative diseases as well as cancer (77)

Neutrophil function: from mechanisms to disease

Our laboratory demonstrated oxidation and decreased levels of Pin1 in MCI and AD brain [9