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In the first step, we used this bioinformatic pipeline to track macrophage polarization over the course of the zymosaninduced inflammation

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Active gene promoters are enriched with activation marks such as H3K27ac, which loosen chromatin structure [41], while repressive regions are covered by marks such as H3K27me3 to maintain a heterochromatic state [42, 43]

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doi: 10.1016/j.jtauto.2020.100073 258 GomesCZunigaMCrottyKAQianKTovarNCLinLHet al