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These findings are the consequence of a decreased liver function

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Choosing outcomes for clinical trials: a pragmatic perspective

Due to the risk of further depletion of the glutamine/glutamate pool, the routine use of sodium phenylbutyrate or phenylacetate to treat hyperammonemia should be considered with extreme caution in MMA and PA [117]-[119]

The efficiency of the absorption tends to diminish as the dose of L-carnitine increases, with some studies finding absorption of L-carnitine is saturated beyond doses of 2 g/12 h [25,26]

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