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Genetic, epigenetic, and environmental factors likely contribute as well

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Treatment of ADHD comorbid with tic disorders cannot be ignored given the impact that ADHD has on these patients, and MPH appears to be the best-tolerated stimulant compound in such patients (Kurlan, 2003[63])

The result is profound orthostatic intolerance, where the simple act of standing up triggers a cascade of debilitating symptoms, including tachycardia, dizziness, and severe shortness of breath, all rooted in a fundamental lack of cellular energy

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