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In diabetes, excess glucose accelerates AGE generation that leads to intra- and extracellular protein cross-linking and protein aggregation

In each study following a 4-week single-blind placebo baseline period, patients were randomized, under double blind conditions, to Depakote or placebo for a 12-week treatment phase, comprised of a 4-week dose titration period followed by an 8-week maintenance period

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doi: 10.1073/pnas.0810962106