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Currently, hormetic nutrients and agents modulating vitagenes are also drawing increasing attention of inhibiting ferroptosis due to their protection against oxidative stress and neuroinflammation in CNS diseases

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Notably, cysteinylglycine has a lower pKa and can more readily form thiolate that reduces Fe3+, potentially fueling Fenton chemistry and lipid oxidationillustrating context-dependent prooxidant effects of extracellular GSH catabolism

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Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts

The activation of the epidermal growth factor receptor (EGFR) signaling pathway has been shown to inhibit the formation of autophagosomes, which are mediated by beclin-1 and LC3B