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10.1038/s41589-019-0408-1 13 CowanA.JeyakumarN.KangY.DixonS

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Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology

Transsulfuration is a significant source of sulfur for glutathione production in human mammary epithelial cells

Cardiovascular tissue displays robust circadian oscillations in cells including vascular smooth muscle, fibroblasts, cardiomyocytes, and cardiac progenitor-like cells, all of which regulate physiological functions including endothelial function, blood pressure, and heart rate (Paschos and FitzGerald, 2010)
