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Leaky gut is commonly recognized in functional medicine but remains controversial in conventional medicine, which acknowledges increased intestinal permeability in conditions like celiac or Crohns disease but may not classify it as a standalone diagnosis

Acknowledgments The authors thank the University of Arkansas Division of Agriculture for its support

It is important to highlight that flavonoid compounds are poorly absorbed in the gut and their concentrations in target tissues are often too low to perform an effective antioxidant defense as reviewed by Surai [105]