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Due to the essential dependence of viruses on the metabolic networks of their host for reproduction 11 , the utilization of in silico models of virally infected cells provides new avenues to identify druggable targets for antiviral therapy 12

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As he points out, this altered glutathione/oxidized glutathione ratio in the substantia nigra suggests that oxidative stress may be a component in the pathogenesis of nigral cell death in PD