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(And even if they were approved, pharmaceutical companies would shy away from them for fear of being undercut by compounding pharmacies.) If companies can sell them and make lots of money without having to prove that they do what theyre claimed to do, why wouldnt they? Zettler points out

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Also, oncogenic mutations that trigger MET activation do not necessarily trigger MET overexpression [101]

It needs to be emphasized that this strategy should be applicable to any cell surface protein of sorting pathway, regardless of physiological activity of targeting proteins

Commun Biol 4 , 310 (2021)