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In a type II collagen-induced arthritis (CIA) model, Lee et al

The middle shelves or vegetable drawer offer the best combination of consistent temperature and light protection

Enhances IGF-1 (Insulin-like Growth Factor 1) production, amplifying tissue repair and anabolic processes

PMID: 30098070 51

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The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions