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Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study

The following are the more likely side effects experienced with peptides: Injection site discomfort Changes in blood pressure, either increases or decreases depending on the peptide Fatigue and dizziness Hot or cold feelings Kidney and liver toxicity Potential toxicity to fetuses Abnormal heart rhythms Increased feelings of hunger Joint pain Tingling or numbness Water retention (this is a sign of overdose) Weight gain or loss Peptides with anabolic effects should not be considered for those with history or at risk of cancer Most side effects are localized and self-limiting

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Airway epithelial cells cocultured with eosinophils increased MUC5AC secretion directly in an amphiregulin- and TGF--dependent mechanism (Shimizu et al., 2014)