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In SCD, abnormal haemoglobin causes red blood cells to stiffen into a characteristic sickle shape under low-oxygen conditions

Expression of proinflammatory cytokines via HIF-1alpha and NF-kappaB activation on desferrioxamine-stimulated HMC-1 cells

To regulate gene expression, Nrf2 will bind to the antioxidant response element (ARE) located in the promoter or enhancer region of target genes (Rushmore et al, 1991
3.5 High mobility group box 1 and inflammatory signaling HMGB1, a nuclear protein, functions as a transcription factor and a DAMP that amplifies inflammatory responses (45)

Campbell TC, Caedo JP, Bulato-Jayme J et al (1970) Aflatoxin M1 in human urine
