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doi: 10.1016/0014-4835(75)90053-6 90 TruscottRJW

Patients pursuing longevity-focused interventions should prioritise interventions that improve GSH:GSSG ratio: resistance training (which upregulates glutathione synthesis), glycine supplementation (35g daily has been shown to improve GSH:GSSG in older adults), adequate sleep (sleep deprivation suppresses glutathione reductase, the enzyme that regenerates GSH from GSSG), and avoidance of chronic alcohol consumption (ethanol metabolism depletes glutathione rapidly)

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And in a mouse model with a genetic deletion of GPX4, MK-4 showed a protective effect on tissues (Mishima et al., 2022)