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Signs of Vitamin B12 Deficiency Vitamin B12 deficiency can develop gradually, and symptoms may range from mild to more noticeable

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49 , 50 , 51 , 52 In the canonical pathway of ADO production, ectonucleoside triphosphate diphosphohydrolase1 (CD39) converts ATP to ADP, and then to adenosine monophosphate (AMP)

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Neurotrauma 19 , 427438 (2002)

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%