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Methylglyoxal, the Dark Side of Glycolysis

In summary, the involvement of GSH in the carcinogenesis and in the drug resistance of tumor cell is clear, but further studies, aimed at understanding the GSH-driven molecular pathways, might be crucial to design new therapeutic strategies to fight cancer progression and overcome chemoresistance

To test whether the MTS pathway was supporting the TR/GR-null livers, we treated mice with single-dose challenges by inhibitors of cystine uptake (sulfasalazine, SSZ), possible cysteine uptake (2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, BCH), conversion of methionine into cysteine by MTS (propargylglycine, PPGG, which inhibits trans -sulfuration and not the methionine cycle), or synthesis of GSH (BSO) 11