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During oxidative stress, ALDHs provide cytoprotection by metabolizing aminoaldehydes to their corresponding amino acids [56]

This infection leads to inflammatory demyelination in brain and spinal cord, with a mixture of cluster of differentiation (CD)4 + and CD8 + T-cells, B-cells, microglia, and macrophages contributing to the demyelination [14]

A recent study revealed that berberine directly targets the NEK7 protein, specifically by blocking the NEK7-NLRP3 interaction and continuously inhibiting IL-1 release

10.4049/jimmunol.1402101 25 RenX.LiangF.HeZ.FanB.ZhangZ.GuoX.et al (2021)

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