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doi: 10.1249/00003677-199800260-00013 368 MyhillSBoothNEMcLaren-HowardJ

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This review focusses on the commonly used antineoplastic substances oxaliplatin, cisplatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycleleading to cell death and tumor degradationand cause severe acute and chronic peripheral neuropathies

It involves the coordinated interaction of multiple biological processes, including: Cell migration to the site of injury Formation of new blood vessels (angiogenesis) Fibroblast activation Extracellular matrix remodeling Regulation of the inflammatory response Cytoskeletal organization For this reason, research is increasingly focused on combining peptides that possess distinct yet complementary mechanisms of action