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Similar G1 arrest by 13-O-acetylsolstitialin A and Tetrandrine has been observed, both of which act on the cyclin D1-CDK4 complex: 13-O-acetylsolstitialin A decreases the expression of cyclin D1 and CDK4 156 , whereas Tetrandrine binds the cyclin D1-CDK4 complex and forms hydrogen bonds 157

doi:10.1016/S1011-1344(02)00277-4

Abouelmagd, S

Alternatively, low pericyte coverage detected in the vasculature of certain tumors reduces vascular stability and increases vascular permeability which impairs the delivery of anticancer therapies to tumor cells and allows them to metastasize (Meng et al., 2015)