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Owing to its exclusive activity towards reduced glutathione, ChaC1 upregulation results in not only glutathione depletion but in alterations in cellular redox ratios (47)

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12.2.1 Potential synergistic effects In some preclinical studies, curcumin has shown the ability to enhance the efficacy of certain chemotherapeutic agents (e.g., paclitaxel, gemcitabine, cisplatin) by sensitizing cancer cells to the drugs, inhibiting drug resistance, and promoting apoptosis