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The APOE 4/4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimers disease patients
Cruz-Aguado R, Francis-Turner L, Daz-Surez CM, Bergado J
Plant Cell 17:18661875 Foyer CH, Noctor G (2011) Ascorbate and glutathione: the heart of the redox hub
Glutathione: subcellular distribution and membrane transport (1)
That view seemed to be supported by the discovery that one cellular response to hydrogen peroxide is the induction of glutaredoxin 1 and thioredoxin 2
Thus, the ratio of GSH to GSSG, which is about 100 : 1 in the liver because of the high metabolic activity, can be influenced by uncontrolled ROS generation and by the defect in GSH biosynthesis
