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TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA

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Trimethylamine and trimethylamine N-oxide, a Flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic Axis implicated in health and disease

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