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doi: 10.1016/0006-2952(86)90121-8

doi:10.1097/01.Jaa.0000511800.91372.34

13: Conditioning Regimens and lymphodepletion O103 Allogeneic hematopoietic cell transplantation with briquilimab anti-CD117 antibody-based nonmyeloablative conditioning for GATA2 deficiency Danielle Arnold 1 , Ira Kraft 1 , Lisa Duncan 1 , Roxanne Merkel 1 , Katherine Calvo 2 , Daniele Avila 1 , Janel Long-Boyle 3 , Wendy Pang 4 , Steven Holland 5 , Dennis Hickstein 1 1 National Cancer Institute, Bethesda, United States of America (the), 2 National Institutes of Health, Bethesda, United States of America (the), 3 University of California San Francisco, San Francisco, United States of America (the), 4 Japser Therapeutics, Redwood City, United States of America (the), 5 National Institutes of Allergy and Infectious Diseases, Bethesda, United States of America (the) Background : GATA2 deficiency is associated with a wide spectrum of disease, including immunodeficiency with increased risk of certain infections, bone marrow failure, and myeloid malignancies

NAIP, CIITA, HET-E, TP-2 (NACHT), and leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) are key components of the inflammasome complex, and multiple signals and stimuli trigger formation of the NLRP3 inflammasome complex 75

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However they also show differences in the overall fold with the presence of a DsbA-like domain inserted within the N-terminal thioredoxin-like domain 6