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Bacteriol Rev 41:100180 Thomas MD (1958) Assimilation of sulfur and physiology of essential S-compounds

This causes molecular changes within the cells and ultimately leads to their death [23]

As outlined above, MeHg can interact with the thiol (SH) groups of glutathione and selenol (SeH) groups of antioxidant selenoenzymes such as glutathione peroxidase (GPx) and thioredoxin reductase (TrxR)

Missiakas et al., 1993

Once bound to VDR, 1,25(OH) 2 VD translocates to the nucleus and controls the transcription of target genes

Biomarkers of disease progression In addition to aiding precise and early diagnosis of PD, biomarkers of disease progression are needed for monitoring outcomes in the clinic and in clinical trials