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Phase 1/2 trial reported no serious adverse events at doses up to 60 mcg/kg (Teichman et al., J Clin Endocrinol Metab 2006)
This, coupled with an increase in a protein called vascular endothelial growth factor (VEGF), allows capillaries (or very small blood vessels) to grow up from the choroid into the retina, ultimately leading to blood and protein leakage below the macula (wet form AMD) (Friedman 2004
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Science 2014;345:1255263
Page AL, Miller RH, Keeny DR
(PubMed) Delaney CL, Spark JI, Thomas J, Wong YT, Chan LT, Miller MD
