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The optimum time to induce ECD by starvation was 96 h since a decrease in angiogenic and migratory capabilities, as well as an increase in recognized markers of senescence, such as -galactosidase, were observed [116]

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GHK-Cu also suppresses the over expression of transforming growth factor-beta (TGF-)1 that has been noted in patients with hereditary hair loss, leading to hair shaft thickening and elongation

cruzi (Alvarez et al., 2017) found that Tc ATG8.1 expression and mTOR-dependent autophagy were induced during early stages of metacyclogenesis and showed that spermidine and related polyamines positively regulated autophagy and differentiation of epimastigote to metacyclic trypomastigote form (Vanrell et al., 2017)

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