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Subjects were initially treated for 6 months of on-demand therapy and then randomized to 12 months of either a standard prophylaxis regimen (20 to 40 IU/kg every 48 hours) or PK-driven prophylaxis regimen (20 to 80 IU/kg every 72 hours)

116,406,407,408 The downstream mediators of TLR7 and TLR9 signaling include IFN- and IL-21

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Step 2 - Use glutathione soap in place of ordinary soap and facewash

84 The initial hypothesis that inducible nitric oxide synthase (iNOS) in Kupffer cells is a significant source of NO formation 85 was quickly dismissed, as iNOS was not consistently induced in different models 86 and iNOS inhibitors did not provide protection

Thomas, R