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Patients with contact sensitivities to preservatives, fragrances, dyes, or specific vehicle ingredients may react to a commercial products inactive ingredients

From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)

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